カミヤ　コウヘイ   Kamiya Kohei   神谷　昂平    所属   東邦大学  医学部 医学科（大森病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Spatial distribution of multiple sclerosis lesions in the cervical spinal cord.
掲載誌名	正式名：Brain : a journal of neurology ISSNコード：00068950
出版社	OXFORD UNIV PRESS
巻・号・頁	142(3),pp.633-646
著者・共著者	Dominique Eden,Charley Gros,Atef Badji,Sara M Dupont,Benjamin De Leener,Josefina Maranzano,Ren Zhuoquiong,Yaou Liu,Tobias Granberg,Russell Ouellette,Leszek Stawiarz,Jan Hillert,Jason Talbott,Elise Bannier,Anne Kerbrat,Gilles Edan,Pierre Labauge,Virginie Callot,Jean Pelletier,Bertrand Audoin,Henitsoa Rasoanandrianina,Jean-Christophe Brisset,Paola Valsasina,Maria A Rocca,Massimo Filippi,Rohit Bakshi,Shahamat Tauhid,Ferran Prados,Marios Yiannakas,Hugh Kearney,Olga Ciccarelli,Seth A Smith,Constantina Andrada Treaba,Caterina Mainero,Jennifer Lefeuvre,Daniel S Reich,Govind Nair,Timothy M Shepherd,Erik Charlson,Yasuhiko Tachibana,Masaaki Hori,Kouhei Kamiya,Lydia Chougar,Sridar Narayanan,Julien Cohen-Adad
発行年月	2019/03
概要	Spinal cord lesions detected on MRI hold important diagnostic and prognostic value for multiple sclerosis. Previous attempts to correlate lesion burden with clinical status have had limited success, however, suggesting that lesion location may be a contributor. Our aim was to explore the spatial distribution of multiple sclerosis lesions in the cervical spinal cord, with respect to clinical status. We included 642 suspected or confirmed multiple sclerosis patients (31 clinically isolated syndrome, and 416 relapsing-remitting, 84 secondary progressive, and 73 primary progressive multiple sclerosis) from 13 clinical sites. Cervical spine lesions were manually delineated on T2- and T2*-weighted axial and sagittal MRI scans acquired at 3 or 7 T. With an automatic publicly-available analysis pipeline we produced voxelwise lesion frequency maps to identify predilection sites in various patient groups characterized by clinical subtype, Expanded Disability Status Scale score and disease duration. We also measured absolute and normalized lesion volumes in several regions of interest using an atlas-based approach, and evaluated differences within and between groups. The lateral funiculi were
DOI	10.1093/brain/awy352
PMID	30715195