カミヤ　コウヘイ   Kamiya Kohei   神谷　昂平    所属   東邦大学  医学部 医学科（大森病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Prospective estimation of mean axon diameter and extra-axonal space of the posterior limb of the internal capsule in patients with idiopathic normal pressure hydrocephalus before and after a lumboperitoneal shunt by using q-space diffusion MRI.
掲載誌名	正式名：European radiology ISSNコード：09387994
出版社	SPRINGER
巻・号・頁	26(9),pp.2992-8
著者・共著者	Masaaki Hori,Kouhei Kamiya,Atsushi Nakanishi,Issei Fukunaga,Masakazu Miyajima,Madoka Nakajima,Michimasa Suzuki,Yuriko Suzuki,Ryusuke Irie,Koji Kamagata,Hajime Arai,Shigeki Aoki
発行年月	2016/09
概要	OBJECTIVES: To prospectively estimate the mean axon diameter (MAD) and extracellular space of the posterior limb of the internal capsule (PLIC) in patients with idiopathic normal pressure hydrocephalus (iNPH) before and after a lumboperitoneal (LP) shunting operation using q-space diffusion MRI analysis. METHODS: We studied 12 consecutive patients with iNPH and 12 controls at our institution. After conventional magnetic resonance imaging (MRI), q-space image (QSI) data were acquired with a 3-T MRI scanner. The MAD and extra-axonal space of the PLIC before and after LP shunting were calculated using two-component q-space imaging analyses; the before and after values were compared. RESULTS: After LP shunt surgery, the extracellular space of the PLIC was significantly higher than that of the same patients before the operation (one-way analysis of variance (ANOVA) with Scheffé's post-hoc test, P = 0.024). No significant differences were observed in the PLIC axon diameters among normal controls or in patients before and after surgery. CONCLUSION: Increases in the root mean square displacement in the extra-axonal space of the PLIC in patients with iNPH after an LP shunt procedure ar
DOI	10.1007/s00330-015-4162-9
PMID	26694062