カミヤ　コウヘイ   Kamiya Kohei   神谷　昂平    所属   東邦大学  医学部 医学科（大森病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Diffusional Kurtosis Imaging in Idiopathic Normal Pressure Hydrocephalus: Correlation with Severity of Cognitive Impairment.
掲載誌名	正式名：Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine ISSNコード：13473182
出版社	JPN SOC MAGNETIC RESONANCE MEDICINE
巻・号・頁	15(3),pp.316-23
著者・共著者	Kouhei Kamiya,Koji Kamagata,Masakazu Miyajima,Madoka Nakajima,Masaaki Hori,Kohei Tsuruta,Harushi Mori,Akira Kunimatsu,Hajime Arai,Shigeki Aoki,Kuni Ohtomo
発行年月	2016/07
概要	PURPOSE: Diffusional kurtosis imaging (DKI) is an emerging technique that describes diffusion of water molecules in terms of deviation from Gaussian distribution. This study investigated correlations between DKI metrics and cognitive function in patients with idiopathic normal pressure hydrocephalus(iNPH). MATERIALS AND METHODS: DKI was performed in 29 iNPH patients and 14 age-matched controls. Mini-mental state examination (MMSE), frontal assessment battery (FAB), and trail making test A (TMT-A) were used as cognitive measures. Tract-based spatial statistics (TBSS) analyses were performed to investigate the between-group differences and correlations with the cognitive measures of the diffusion metrics, including mean kurtosis (MK), fractional anisotropy (FA), apparent diffusion coefficient (ADC), axial diffusivity (AD), and radial diffusivity (RD). RESULTS: In iNPH patients, FA and MK identified positive correlations with cognitive function in similar regions, predominantly in the frontal lobes (P<0.05, corrected for multiple comparisons). The frontoparietal subcortical white matter showed significant correlations with FAB and TMT-A across more extensive areas in MK analyses th
DOI	10.2463/mrms.mp.2015-0093
PMID	26841854