カミヤ　コウヘイ   Kamiya Kohei   神谷　昂平    所属   東邦大学  医学部 医学科（大森病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Alterations of the optic pathway between unilateral and bilateral optic nerve damage in multiple sclerosis as revealed by the combined use of advanced diffusion kurtosis imaging and visual evoked potentials.
掲載誌名	正式名：Magnetic resonance imaging ISSNコード：0730725X
出版社	ELSEVIER SCIENCE INC
巻・号・頁	39,pp.24-30
著者・共著者	Mariko Yoshida Takemura,Masaaki Hori,Kazumasa Yokoyama,Nozomi Hamasaki,Michimasa Suzuki,Koji Kamagata,Kouhei Kamiya,Yuriko Suzuki,Shinsuke Kyogoku,Yoshitaka Masutani,Nobutaka Hattori,Shigeki Aoki
発行年月	2017/06
概要	OBJECTIVES: We investigated changes in the optic tract and optic radiation in patients with multiple sclerosis (MS) by comparing unilateral and bilateral optic nerve damage assessed based on visual evoked potentials (VEPs) using advanced diffusion MR metrics. METHODS: In 21 MS patients, diffusion MRI was performed. Maps of fractional anisotropy, apparent diffusion coefficient (ADC), and mean kurtosis (MK) were computed. On the basis of the P100 latency in VEPs, the MS patients were divided into three groups: bilateral (n=7), unilateral (n=7), and no abnormality (n=7). Their optic tracts and optic radiations were analyzed with diffusion MRI-based fiber tracking. We also investigated the correlations between diffusion parameters and VEPs (n=21). RESULTS: In the optic tract, the diffusion changes in each of the three groups showed step-like changes. The diffusion changes in the optic radiations of the unilateral group were similar to those in the normal VEP group. Only the bilateral group showed significantly higher ADC and lower MK relative to the other two groups (P<0.05, Steel-Dwass multiple-comparison test). A significant positive correlation between VEP latency and ADC and a sign
DOI	10.1016/j.mri.2016.04.011
PMID	27109488