カミヤ　コウヘイ   Kamiya Kohei   神谷　昂平    所属   東邦大学  医学部 医学科（大森病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	In vivo evaluation of gray and white matter volume loss in the parkinsonian variant of multiple system atrophy using SPM8 plus DARTEL for VBM.
掲載誌名	正式名：NeuroImage. Clinical ISSNコード：22131582
出版社	ELSEVIER SCI LTD
巻・号・頁	2,pp.491-6
著者・共著者	Yoko Shigemoto,Hiroshi Matsuda,Kouhei Kamiya,Norihide Maikusa,Yasuhiro Nakata,Kimiteru Ito,Miho Ota,Naofumi Matsunaga,Noriko Sato
発行年月	2013/04
概要	In multiple system atrophy with predominant parkinsonism (MSA-P), several voxel-based morphometry (VBM) studies have revealed gray matter loss; however, the white matter volume changes have been rarely reported. We investigated the volume changes of white matter as well as gray matter by VBM. A retrospective MRI study was performed in 20 patients with MSA-P and 30 age-matched healthy controls. We applied VBM with statistical parametric mapping (SPM8) plus diffeomorphic anatomical registration through exponentiated Lie algebra (DARTEL) to explore the regional atrophy of gray and white matter in all of the MSA-P patients, 14 patients with left-side dominant and 6 patients with right-side dominant onset as compared to controls. In all of the MSA-P patients, VBM revealed a significant volume reduction of gray matter in the bilateral putamina, cerebellums and dorsal midbrain. White matter loss was located in bilateral globus pallidi, external capsules extending to the midbrain, right subcortical to precentral area through internal capsule, the pons, bilateral middle cerebellar peduncles and left cerebellum.In left-side dominant MSA-P patients, the gray and white matter volume loss was
DOI	10.1016/j.nicl.2013.03.017
PMID	24179801