カミヤ　コウヘイ   Kamiya Kohei   神谷　昂平    所属   東邦大学  医学部 医学科（大森病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	A preliminary diffusional kurtosis imaging study of Parkinson disease: comparison with conventional diffusion tensor imaging.
掲載誌名	正式名：Neuroradiology ISSNコード：00283940
出版社	SPRINGER
巻・号・頁	56(3),pp.251-8
著者・共著者	Koji Kamagata,Hiroyuki Tomiyama,Taku Hatano,Yumiko Motoi,Osamu Abe,Keigo Shimoji,Kouhei Kamiya,Michimasa Suzuki,Masaaki Hori,Mariko Yoshida,Nobutaka Hattori,Shigeki Aoki
発行年月	2014/03
概要	INTRODUCTION: Diffusional kurtosis imaging (DKI) is a more sensitive technique than conventional diffusion tensor imaging (DTI) for assessing tissue microstructure. In particular, it quantifies the microstructural integrity of white matter, even in the presence of crossing fibers. The aim of this preliminary study was to compare how DKI and DTI show white matter alterations in Parkinson disease (PD). METHODS: DKI scans were obtained with a 3-T magnetic resonance imager from 12 patients with PD and 10 healthy controls matched by age and sex. Tract-based spatial statistics were used to compare the mean kurtosis (MK), mean diffusivity (MD), and fractional anisotropy (FA) maps of the PD patient group and the control group. In addition, a region-of-interest analysis was performed for the area of the posterior corona radiata and superior longitudinal fasciculus (SLF) fiber crossing. RESULTS: FA values in the frontal white matter were significantly lower in PD patients than in healthy controls. Reductions in MK occurred more extensively throughout the brain: in addition to frontal white matter, MK was lower in the parietal, occipital, and right temporal white matter. The MK value of the a
DOI	10.1007/s00234-014-1327-1
PMID	24468858