カミヤ　コウヘイ   Kamiya Kohei   神谷　昂平    所属   東邦大学  医学部 医学科（大森病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Multiple sclerosis: Benefits of q-space imaging in evaluation of normal-appearing and periplaque white matter.
掲載誌名	正式名：Magnetic resonance imaging ISSNコード：0730725X
出版社	ELSEVIER SCIENCE INC
巻・号・頁	32(6),pp.625-9
著者・共著者	Masaaki Hori,Mariko Yoshida,Kazumasa Yokoyama,Koji Kamagata,Fumitaka Kumagai,Issei Fukunaga,Kouhei Kamiya,Michimasa Suzuki,Yoshitaka Masutani,Nozomi Hamasaki,Yuriko Suzuki,Shinsuke Kyogoku,Nobutaka Hattori,Shigeki Aoki
発行年月	2014/07
概要	INTRODUCTION: Diffusion tensor imaging (DTI) reveals white matter pathology in patients with multiple sclerosis (MS). A recent non-Gaussian diffusion imaging technique, q-space imaging (QSI), may provide several advantages over conventional MRI techniques in regard to in vivo evaluation of the disease process in patients with MS. The purpose of this study is to investigate the use of root mean square displacement (RMSD) derived from QSI data to characterize plaques, periplaque white matter (PWM), and normal-appearing white matter (NAWM) in patients with MS. METHODS: We generated apparent diffusion coefficient (ADC) and fractional anisotropy (FA) maps by using conventional DTI data from 21 MS patients; we generated RMSD maps by using QSI data from these patients. We used the Steel-Dwass test to compare the diffusion metrics of regions of interest in plaques, PWM, and NAWM. RESULTS: ADC differed (P<0.05) between plaques and PWM and between plaques and NAWM. FA differed (P<0.05) between plaques and NAWM. RMSD differed (P<0.05) between plaques and PWM, plaques and NAWM, and PWM and NAWM. CONCLUSION: RMSD values from QSI may reflect microstructural changes and white-matter damage in pat
DOI	10.1016/j.mri.2014.02.024
PMID	24726649