カミヤ　コウヘイ   Kamiya Kohei   神谷　昂平    所属   東邦大学  医学部 医学科（大森病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Differential diagnosis tool for parkinsonian syndrome using multiple structural brain measures.
掲載誌名	正式名：Computational and mathematical methods in medicine ISSNコード：1748670X
出版社	HINDAWI LTD
巻・号・頁	2013,pp.571289-571289
著者・共著者	Miho Ota,Yasuhiro Nakata,Kimiteru Ito,Kouhei Kamiya,Masafumi Ogawa,Miho Murata,Satoko Obu,Hiroshi Kunugi,Noriko Sato
発行年月	2013/03
概要	Clinical differentiation of parkinsonian syndromes such as the Parkinson variant of multiple system atrophy (MSA-P) and cerebellar subtype (MSA-C) from Parkinson's disease is difficult in the early stage of the disease. To identify the correlative pattern of brain changes for differentiating parkinsonian syndromes, we applied discriminant analysis techniques by magnetic resonance imaging (MRI). T1-weighted volume data and diffusion tensor images were obtained by MRI in eighteen patients with MSA-C, 12 patients with MSA-P, 21 patients with Parkinson's disease, and 21 healthy controls. They were evaluated using voxel-based morphometry and tract-based spatial statistics, respectively. Discriminant functions derived by step wise methods resulted in correct classification rates of 0.89. When differentiating these diseases with the use of three independent variables together, the correct classification rate was the same as that obtained with step wise methods. These findings support the view that each parkinsonian syndrome has structural deviations in multiple brain areas and that a combination of structural brain measures can help to distinguish parkinsonian syndromes.
DOI	10.1155/2013/571289
PMID	23573171