カミヤ　コウヘイ   Kamiya Kohei   神谷　昂平    所属   東邦大学  医学部 医学科（大森病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Differentiation of high-grade and low-grade intra-axial brain tumors by time-dependent diffusion MRI.
掲載誌名	正式名：Magnetic resonance imaging ISSNコード：0730725X
出版社	ELSEVIER SCIENCE INC
巻・号・頁	72,pp.34-41
著者・共著者	Tomoko Maekawa,Masaaki Hori,Katsutoshi Murata,Thorsten Feiweier,Kouhei Kamiya,Christina Andica,Akifumi Hagiwara,Shohei Fujita,Saori Koshino,Toshiaki Akashi,Koji Kamagata,Akihiko Wada,Osamu Abe,Shigeki Aoki
発行年月	2020/10
概要	INTRODUCTION: Oscillating gradient spin-echo (OGSE) sequences enable acquisitions with shorter diffusion times. There is growing interest in the effect of diffusion time on apparent diffusion coefficient (ADC) values in patients with cancer. However, little evidence exists regarding its usefulness for differentiating between high-grade and low-grade brain tumors. The purpose of this study is to investigate the utility of changes in the ADC value between short and long diffusion times in distinguishing low-grade and high-grade brain tumors. MATERIAL AND METHODS: Eleven patients with high-grade brain tumors and ten patients with low-grade brain tumors were scanned using a 3 T magnetic resonance imaging with diffusion-weighted imaging (DWI) using OGSE and PGSE (effective diffusion time [Δeff]: 6.5 ms and 35.2 ms) and b-values of 0 and 1000 s/mm2. Using a region of interest (ROI) analysis of the brain tumors, we measured the ADC for two Δeff (ADCΔeff) values and computed the subtraction ADC (ΔADC = ADC6.5 ms - ADC35.2 ms) and the relative ADC (ΔADC = (ADC6.5 ms - ADC35.2 ms) / ADC35.2 ms × 100). The maximum values for the subtraction ADC (ΔADCmax) and the relative
DOI	10.1016/j.mri.2020.06.018
PMID	32599021