ミカミ　テツオ   Mikami Tetsuo   三上　哲夫    所属   東邦大学  医学部 医学科    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Prognostic values of L-type amino acid transporter 1 and CD98hc expression in breast cancer
掲載誌名	正式名：Journal of clinical pathology 略　 称：J Clin Pathol ISSNコード：00219746/14724146
掲載区分	国外
出版社	British Medical Association
巻・号・頁	74(9),pp.589-595
著者・共著者	Ichinoe M, Mikami T†, Yanagisawa N, Yoshida T, Hana K, Endou H, Okayasu I, Sengoku N, Ogata H†, Saegusa M, Shibuya K†, Murakumo Y.
担当区分	2nd著者
発行年月	2021/09
概要	Aims: L-type amino acid transporter 1 (LAT1) is a major Na+-independent neutral amino acid transporter, forming a complex with CD98hc. The aim of this study is to investigate the significance of LAT1 and CD98hc in invasive breast cancer. Methods: LAT1 and CD98hc expression was immunohistochemically assessed in 280 invasive breast cancers and analysed for association with clinicopathological features. Results: High levels of LAT1 and CD98hc were observed in triple-negative breast cancers (TNBCs) possessing negative immunoreactivity with oestrogen receptor, progesterone receptor and human epidermal growth factor receptor 2, compared with non-TNBCs (NTNBCs), and were associated with lymph-node metastasis and higher nuclear grade. The high-LAT1-expression group showed a poor prognosis in NTNBC and TNBC, however, high-CD98hc-expression group showed a poor prognosis only in NTNBC. LAT1 and CD98hc expression could be the prognostic factors in univariate analyses, but not in multivariate analyses. Further, we found that invasive tumour components showed higher LAT1 and CD98hc expression than non-invasive tumour components. Conclusions: LAT1 and CD98hc may possess prognostic values in invasive breast cancer. LAT1 may be linked with cancer cell activities and disease progression in breast cancer.