ホリ　マサアキ   Hori Masaaki   堀　正明    所属   東邦大学  医学部 医学科（大森病院）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Three-dimensional high-resolution simultaneous quantitative mapping of the whole brain with 3D-QALAS: An accuracy and repeatability study.
掲載誌名	正式名：Magnetic resonance imaging 略　 称：Magn Reson Imaging ISSNコード：18735894/0730725X
掲載区分	国外
巻・号・頁	63,pp.235-243
著者・共著者	Fujita S, Hagiwara A, Hori M†, Warntjes M, Kamagata K, Fukunaga I, Andica C, Maekawa T, Irie R, Takemura M-Y, Kumamaru K- K, Wada A, Suzuki M, Ozaki Y, Abe O, Aoki S
発行年月	2019/11
概要	BACKGROUND:Previous methods for the quantification of brain tissue properties by magnetic resonance imaging were mainly based on two-dimensional acquisitions and were thus limited to a relatively low resolution in the slice direction compared to three-dimensional (3D) acquisitions. The 3D-quantification using an interleaved Look-Locker acquisition sequence with a T2 preparation pulse (3D-QALAS) sequence may allow for simultaneous acquisition of relaxometry parameters in high spatial resolution.PURPOSE:To evaluate bias, linearity, and day-to-day repeatability of relaxometry parameters, as well as tissue fraction maps, acquired with 3D-QALAS.MATERIALS AND METHODS:Scan-rescan test of the 3D-QALAS sequence was performed on a 1.5-T scanner with the International Society for Magnetic Resonance in Medicine/National institute of Standards and Technology system phantom and 10 healthy volunteers (7 male, 3 female; mean age, 23.2 ± 3.6 years). Simple linear regression analysis, Bland-Altman plots, and intrasubject coefficients of variation (CV) were used to assess the reliability of 3D-QALAS sequence-derived parameters. The T1, T2, proton density (PD), and myelin volume fraction (MVF) of in vivo brain regions were compared with values obtained using the multidynamic multi-echo sequence.RESULTS:In the phantom study, the T1, T2, and PD values measured by 3D-QALAS showed strong linearity with the reference values (R2CONCLUSION:3D-QALAS enables reliable measurement of T1, T2, PD, and MVF values of the whole brain in high spatial resolution across a clinically-relevant dynamic range.
DOI	10.1016/j.mri.2019.08.031
PMID	31445118