ホリ　マサアキ   Hori Masaaki   堀　正明    所属   東邦大学  医学部 医学科（大森病院）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Utility and validity of neurite orientation dispersion and density imaging with diffusion tensor imaging to quantify the severity of cervical spondylotic myelopathy and assess postoperative neurological recovery.
掲載誌名	正式名：The spine journal : official journal of the North American Spine Society 略　 称：Spine J ISSNコード：18781632/15299430
掲載区分	国外
巻・号・頁	20(3),pp.417-425
著者・共著者	Iwama Toru, Ohba Tetsuro, Okita Genki, Ebata Shigeto, Ueda Ryo, Motosugi Utaroh, Onishi Hiroshi, Haro Hirotaka, Hori Masaaki
発行年月	2019/11/01
概要	BACKGROUND CONTEXT:Predicting postoperative prognosis with preoperative diagnostic imaging has clinical importance. Recent studies have indicated the utility of diffusion tensor imaging (DTI) to quantify the severity of cervical spondylotic myelopathy (CSM) and assess the prognosis of surgical outcomes. However, how to apply DTI to evaluate CSM in a clinical setting is not fully elucidated. Neurite orientation dispersion and density imaging (NODDI) is a model-based practical diffusion-weighted magnetic resonance imaging analysis for estimating specific microstructural features related directly to neuronal morphology. In a prior study, we indicated preoperative NODDI parameters are a promising tool with which to predict neuronal recovery after decompression surgery in patients with CSM with 2 years follow-up. However, the correlation between NODDI parameters and postoperative long-term outcomes and change of parameters over time postoperatively has remained largely unknown.STUDY DESIGN:Retrospective cohort study.PURPOSE:To determine the change of parameters of NODDI and conventional DTI over time, and the relationship between parameters and neurological recovery 2 years after surgery.PATIENT SAMPLE:We included 28 consecutive patients with nontraumatic cervical lesions from CSM who underwent laminoplasty and were followed up for>2 years. Patients underwent magnetic resonance imaging before and approximately 2 weeks, 6 months, and 1 year after surgery.OUTCOME MEASURES:In addition to conventional DTI metrics, we evaluated intracellular volume fraction (ICVF) and orientation dispersion index, which are metrics derived from NODDI. The Japanese Orthopedic Association (JOA) scoring system was used before and 2 years after surgery to assess neurological outcome (JOA recovery rate).METHODS:NODDI and conventional DTI values were measured at the C2-C3 intervertebral level (control value) and the most compressed levels (C3-C7 intervertebral levels) were measured by 3 observers.
DOI	10.1016/j.spinee.2019.10.019
PMID	31683067