ホリ　マサアキ   Hori Masaaki   堀　正明    所属   東邦大学  医学部 医学科（大森病院）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Deep Learning Approach for Generating MRA Images From 3D Quantitative Synthetic MRI Without Additional Scans.
掲載誌名	正式名：Investigative radiology 略　 称：Invest Radiol ISSNコード：15360210/00209996
掲載区分	国外
巻・号・頁	55(4),pp.249-256
著者・共著者	Fujita S, Hagiwara A, Otsuka Y, Hori M†, Takei N, Hwang K, Irie R, Andica C, Kamagata K, Akashi T, Kunishima Kumamaru K, Suzuki M, Wada A, Abe O, Aoki S
発行年月	2020/04
概要	OBJECTIVES:Quantitative synthetic magnetic resonance imaging (MRI) enables synthesis of various contrast-weighted images as well as simultaneous quantification of T1 and T2 relaxation times and proton density. However, to date, it has been challenging to generate magnetic resonance angiography (MRA) images with synthetic MRI. The purpose of this study was to develop a deep learning algorithm to generate MRA images based on 3D synthetic MRI raw data.MATERIALS AND METHODS:Eleven healthy volunteers and 4 patients with intracranial aneurysms were included in this study. All participants underwent a time-of-flight (TOF) MRA sequence and a 3D-QALAS synthetic MRI sequence. The 3D-QALAS sequence acquires 5 raw images, which were used as the input for a deep learning network. The input was converted to its corresponding MRA images by a combination of a single-convolution and a U-net model with a 5-fold cross-validation, which were then compared with a simple linear combination model. Image quality was evaluated by calculating the peak signal-to-noise ratio (PSNR), structural similarity index measurements (SSIMs), and high frequency error norm (HFEN). These calculations were performed for deep learning MRA (DL-MRA) and linear combination MRA (linear-MR), relative to TOF-MRA, and compared with each other using a nonparametric Wilcoxon signed-rank test. Overall image quality and branch visualization, each scored on a 5-point Likert scale, were blindly and independently rated by 2 board-certified radiologists.RESULTS:Deep learning MRA was successfully obtained in all subjects. The mean PSNR, SSIM, and HFEN of the DL-MRA were significantly higher, higher, and lower, respectively, than those of the linear-MRA (PSNR, 35.3 ± 0.5 vs 34.0 ± 0.5, P<0.001; SSIM, 0.93 ± 0.02 vs 0.82 ± 0.02, P<0.001; HFEN, 0.61 ± 0.08 vs 0.86 ± 0.05, P<0.001). The overall image quality of the DL-MRA was comparable to that of TOF-MRA (4.2 ± 0.7 vs 4.4 ± 0.7, P = 0.99), and both types of images were superio
DOI	10.1097/RLI.0000000000000628
PMID	31977603