オバラ　ケイスケ   Obara Keisuke   小原　圭将    所属   東邦大学  薬学部 薬学科    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Inhibitory effects of antidepressants on ATP-induced contractions in isolated guinea pig urinary bladder smooth muscle
掲載誌名	正式名：Phamacometrics 略　 称：Phamacometrics
掲載区分	国内
出版社	応用薬理研究会
巻・号・頁	91(1/2),pp.41-48
著者・共著者	Obara K†, Uno J†, Suzuki H†, Miyatani S†, Chino D†, Yoshio T†, Tanaka Y＊†
担当区分	筆頭著者
発行年月	2016/07
概要	This study was designed to investigate the inhibitory effects of 18 commercially available antidepressants on ATP-induced contractions in guinea pig urinary bladder smooth muscle (UBSM) to determine whether they induce voiding impairment. Concentration-response curves for ATP-induced contractions in guinea pig UBSM strips were generated in the absence or presence of selected antidepressants. When inhibitory effects indicated competitive antagonism, pA2 values against ATP were calculated and compared to blood antidepressant concentrations. ATP-induced contractions were competitively antagonized by duloxetine (a serotonin and noradrenaline reuptake inhibitor) and aripiprazole (a dopamine partial agonist). The antagonistic actions of duloxetine and aripiprazole were exerted at concentrations exceeding clinically achievable blood levels based on their pA2 values (5.55 and 5.85, respectively). Other tested antidepressants also did not inhibit ATP-induced contractions of guinea pig UBSM preparations within the concentration ranges used in clinical practice. Antidepressants prescribed in Japan may produce voiding impairment; however, their actions are not mediated via inhibition of UBSM contraction induced by ATP.