オバラ　ケイスケ   Obara Keisuke   小原　圭将    所属   東邦大学  薬学部 薬学科    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Pharmacological characteristics of the inhibitory effects of docosahexaenoic acid (DHA) against vascular contractions studied in rat mesenteric artery.
掲載誌名	正式名：Pharmacology 略　 称：Pharmacology ISSNコード：00317012/14230313
出版社	Karger
巻・号・頁	93(5-6),pp.229-243
著者・共著者	Sato K†, Chino D†, Sugimoto T†, Kanai K†, Obara K†, Miyauchi S†, Tanaka Y＊†.
発行年月	2014/12
概要	Background/Aims: Effects of docosahexaenoic acid (DHA) on the blood vessel contractions to various constrictors were investigated in rat mesenteric artery, and they were compared with those of eicosapentaenoic acid (EPA) and linoleic acid (LA). Methods: Tension changes of mesenteric ring segments were isometrically recorded. Results: Against sustained contractions induced by a TXA2 mimetic U46619, DHA exerted a strong inhibitory effect. The inhibitory effect by DHA against U46619 appeared both in endothelium-intact and endothelium-denuded preparations. Although inhibitory effect of DHA was also significant against PGF2alpha-induced contraction, the contractions to phenylephrine (PE) and high-KCl were not affected by DHA. As well as DHA, EPA strongly diminished U46619- and PGF2alphaPGF2alpha-induced contractions without showing substantial inhibition against PE- and high-KCl-induced contractions. By contrast, LA did not show significant inhibitory effects against any contractions. DHA-induced inhibitory actions exerted against U46619 and PGF2alphaalso emerged when ring preparations were pretreated with this ω-3 polyunsaturated fatty acid (PUFA). Conclusion: DHA and EPA are found to inhibit more pronouncedly prostanoid receptor-mediated contractions than other constrictor responses of mesenteric artery through endothelium-independent mechanisms. These inhibitory effects by ω-3 PUFAs against prostanoid receptor-mediated contractions may partly underlie the mechanisms by which these ω-3 PUFAs elicit protect actions against circulatory disorders.
DOI	10.1159/000360543