フルタ　トシアキ   Furuta Toshiaki   古田　寿昭    所属   東邦大学  理学部 生物分子科学科    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Design, synthesis and photochemistry of modular caging groups for caged nucleotides
掲載誌名	正式名：Organic Letters
掲載区分	国外
巻・号・頁	14(24),pp.6182-6185
著者・共著者	T. Furuta, K. Manabe, A. Teraoka, K. Murakoshi, A. Ohtsubo and A. Suzuki
担当区分	筆頭著者,責任著者
発行年月	2012/12/21
概要	A modular approach to preparing caged nucleotides having additional properties has been achieved. The modular caging agent includes three components: an amine reactive NHS ester moiety, a photoactive Bhc group, and tosylhydrazone as a precursor of the diazomethyl group. Various amines including biotin and an Arg-Gly-Asp (RGD) peptide were introduced into the key intermediate via amide linkage. The Bio-Bhc-diazo thus synthesized enables the preparation of a photoreleasable siRNA with additional properties.