フカサワ　ユリ   Fukasawa Yuri   深澤　由里    所属   東邦大学  医学部 医学科    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Lymphangiogenesis in myocardial remodelling after infarction
掲載誌名	正式名：Histopathology 略　 称：Histopathology ISSNコード：03090167/13652559
出版社	Blackwell Publishing
巻・号・頁	51(3),pp.345-353
著者・共著者	Ishikawa Y＊†, Akishima-Fukasawa Y†, Ito K†, Akasaka Y†, Tanaka M, Shimokawa R, Kimura-Matsumoto M†, Morita H†, Sato S†, Kamata I†, Ishii T†
担当区分	2nd著者
発行年月	2007/09
概要	AIMS: The lymphatic system is involved in fluid homeostasis of the cardiac interstitium, but lymphangiogenesis in myocardial remodelling has not previously been examined histopathologically. The aim was to investigate by D2-40 immunohistochemistry the sequential changes in lymphatic distribution in the process of myocardial remodelling after myocardial infarction (MI). METHODS AND RESULTS: Myocardial tissues in various phases of healing after MI were obtained from 40 autopsied hearts. D2-40+ lymphatic vessel density (LD) and CD34+ blood vessel density (BD) in the lesion were determined. BD decreased with advance of myocardial necrosis, subsequently increased at the early stage of granulation and thereafter decreased with the progression of scar formation. In contrast, lymphatic vessels were not detected in lesions with coagulation necrosis, and newly formed lymphatics first appeared in the early stages of granulation. A subsequent increase in LD was demonstrated in the late stages of granulation, and lymphatics remained up to the scar phase. Vascular endothelial growth factor-C was consistently expressed in viable cardiomyocytes around the lesion in all of these stages. CONCLUSION: In myocardial remodelling after MI, lymphangiogenesis lags behind blood vessel angiogenesis; newly formed lymphatics may be involved mainly in the maturation of fibrosis and scar formation through the drainage of excessive proteins and fluid.
DOI	10.1111/j.1365-2559.2007.02785.x
PMID	17727476