タカハラ　アキラ   Takahara Akira   高原　章    所属   東邦大学  薬学部 薬学科    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	H2 receptor-mediated positive inotropic effect of histamine in neonatal guinea-pig left atria.
掲載誌名	正式名：Biological & Pharmaceutical Bulletin 略　 称：Biol Pharm Bull ISSNコード：09186158
掲載区分	国内
巻・号・頁	33(12),pp.2033-2035
著者・共著者	Agata N†, Kato Y†, Namekata I†, Takahara A†, Tanaka H†＊, Chino D†, Koike K†, Tanaka Y†
発行年月	2010/12
概要	The receptor type mediating the positive inotropic effect of histamine was examined in left atria from neonatal guinea pigs. The positive inotropic effect of histamine, as well as its action potential prolonging effect, was antagonized by ranitidine, but not by chlorpheniramine or thiperamide. The positive inotropic effect was enhanced by isobutylmethylxantine. Receptor binding studies revealed the presence of both H1 and H2 receptor types. These results suggest that the positive inotropic effect of histamine in the neonatal guinea-pig atrium is mediated by H2 receptors.