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サイトウ リョウタ
Saito Ryota
齋藤 良太 所属 東邦大学 理学部 化学科 職種 教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Synthesis of Boradiazaindacene–Imidazopyrazinone Conjugate as Lipophilic and Yellow-Chemiluminescent Chemosensor for Superoxide Radical Anion |
| 掲載誌名 | 正式名：Tetrahedron |
| 掲載区分 | 国外 |
| 巻・号・頁 | 66(3),pp.583-590 |
| 著者・共著者 | Ryota Saito, Ayako Ohno, and Eri Ito |
| 担当区分 | 筆頭著者,責任著者 |
| 発行年月 | 2010/01 |
| 概要 | As a chemiluminescent chemosensor that emits yellow light on reacting with a superoxide radical anion (O2•–) and has a lipophilic character, a 6-phenylimidazo[1,2-a]pyrazin-3(7H)-one derivative possessing a boradiazaindacene (BODIPY) at the para position of 6-phenyl (1) was synthesized. The lipophilicity of 1 was investigated by reversed-phase liquid chromatography, and its logPow value was found to be 3.57. This value was much higher than that of 2-methyl-6-(4-methoxypheyl)imidazo[1,2- a]pyrazin-3(7H)-one (MCLA, logPow = 1.19) and 6-[4-[2-{N′-(5-fluoresceinyl)thioureido}ethoxy]phehyl]-2-methylimidazo[1,2-a]pyrazin-3(7H)-one (FCLA, logPow = –0.08), and it was comparable to that of benzenoid hydrocarbons. The O2•–-induced chemiluminescence of 1 was investigated using the hypoxanthine/xanthine oxidase system as the source of O2•–, and as a result, yellow emission was observed. The maximum wavelength was observed at 542 nm, and it was longer than that of FCLA. |