フカサワ　ユリ   Fukasawa Yuri   深澤　由里    所属   東邦大学  医学部 医学科    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Significance of lymphatic invasion and cancer invasion-related proteins on regional lymph node metastasis of gastric cancer
掲載誌名	正式名：Journal of gastroenterology and hepatology 略　 称：J Gastroenterol Hepatol ISSNコード：08159319/14401746
出版社	Blackwell Scientific Publications
巻・号・頁	24(9),pp.1527-1533
著者・共著者	Kamata I†, Ishikawa Y＊†, Akishima-Fukasawa Y†, Ito K†, Akasaka Y†, Uzuki M†, Fujimoto A†, Morita H†, Tamai S, Maehara T, Ogata K, Shimokawa R, Igarashi Y†, Miki K†, Ishii T†.
発行年月	2009/09
概要	BACKGROUND AND AIMS: Cancer invasion and metastasis are critical events for patient prognosis; however, the most important step in the whole process of lymph node (LN) metastasis in gastric cancer remains obscure. In this study, the significance of cancer cell behaviors, such as cell detachment, stromal invasion and lymphatic invasion on regional LN metastasis in gastric cancer was investigated by comprehensive immunohistochemistry. METHODS: A total of 210 cases with gastric cancer were selected. These consisted of 105 cases with regional LN metastasis (LN[+] group) and 105 cases without LN metastasis (LN[-] group). Both groups exhibited the same depth of invasion. Cancer tissues were subjected to immunohistochemistry with antibodies against claudin-3, claudin-4, beta-catenin, matrix metalloproteinase (MMP)-1, and MMP-2, as well as endothelial markers of lymphatic vessel endothelial hyaluronan receptor-1 and von Willebrand factor for the objective discrimination between lymphatics and blood vessels. The expression of each protein as well as the histopathological parameters were compared between LN(+) and LN(-) groups. RESULTS: Along with lymphatic invasion by cancer cells and gross tumor size, MMP-1 expression in cancer cells at the invasive front of the primary tumor was a significant, independent predictor of LN metastasis. The expression of claudins and beta-catenin was associated with the histopathological type of cancer, but not with LN status. CONCLUSION: Among the cancer invasion-related proteins examined, MMP-1 plays a vital role in LN metastasis of gastric cancer. Tumor size, lymphatic invasion and MMP-1 expression level at the invasive front were the predictive factors of LN metastasis of gastric cancer.
DOI	10.1111/j.1440-1746.2009.05810.x
PMID	19383080