リ　ギ   Li Wei   李　巍    所属   東邦大学  薬学部 薬学科    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Pancreatic lipase-inhibiting triterpenoid saponins from fruits of Acanthopanax senticosus
掲載誌名	正式名：Chemical & pharmaceutical bulletin 略　 称：Chem Pharm Bull (Tokyo) ISSNコード：00092363/13475223
巻・号・頁	55(7),pp.1087-1089
著者・共著者	Fang Li, Wei Li, Hongwei Fu, Qingbo Zhang, Kazuo Koike
担当区分	2nd著者
発行年月	2007
概要	Sixteen triterpenoid saponins were isolated from the fruits of Acanthopanax senticosus, including a new compd., acanthopanaxoside E (1)(I), which was established as 3-O-.beta.-D-glucuronopyranosyl echinocystic acid 28-O-.beta.-D-glucopyranoside on the basis of various spectroscopic analyses and chem. degrdn. By using a pancreatic lipase-inhibiting assay system, the crude saponin fraction showed inhibitory activity on pancreatic lipase, which is a key enzyme in lipid digestion. Among the isolated compds., silphioside F (2), copteroside B (3), hederagenin 3-O-.beta.-D-glucuronopyranoside 6'-O-Me ester (4) and gypsogenin 3-O-.beta.-D-glucuronopyranoside (5) showed inhibitory activity toward pancreatic lipase with IC50 values of 0.22, 0.25, 0.26 and 0.29 mM, resp., and the free carboxylic acid groups in position 28 within their chem. structures were required for enhancement of pancreatic lipase inhibition.