リ　ギ   Li Wei   李　巍    所属   東邦大学  薬学部 薬学科    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Pancreatic lipase-inhibiting triterpenoid saponins from Gypsophila oldhamiana
掲載誌名	正式名：Chemical & pharmaceutical bulletin 略　 称：Chem Pharm Bull (Tokyo) ISSNコード：00092363/13475223
巻・号・頁	55(4),pp.646-650
著者・共著者	Quan Zheng, Wei Li, Likun Han, Kazuo Koike
担当区分	2nd著者,責任著者
発行年月	2007
概要	Three new triterpenoid saponins, gypsosaponins A-C (1-3), were isolated from the roots of Gypsophila oldhamiana (Caryophyllaceae). Their structures were established as 3-O-.beta.-D-galactopyranosyl-(12)-[.beta.-D-xylopyranosyl-(13)]-.beta.-D-glucuronopyranosyl quillaic acid 28-O-.alpha.-L-arabinopyranosyl-(12)-.alpha.-L-arabinopyranosyl-(13)-.beta.-D-xylopyranosyl-(14)-.alpha.-L-rhamnopyranosyl-(12)-.beta.-D-fucopyranoside (1)(I), 3-O-.beta.-D-galactopyranosyl-(12)-[.beta.-D-xylopyranosyl-(13)]-methyl-.beta.-D-glucuronopyranosyl gypsogenin 28-O-.beta.-D-glucopyranosyl-(13)-[.beta.-D-xylopyranosyl-(14)]-.alpha.-L-rhamnopyranosyl-(12)- .beta.-D-fucopyranoside (2), and 23-O-.beta.-D-glucopyranosyl gypsogenic acid 28-O-.beta.-D-glucopyranosyl-(13)-[.beta.-D-glucopyranosyl-(16)]-.beta.-D-glucopyranoside (3), on the basis of various spectroscopic analyses and chem. degrdns. The biol. activities of 1-3 were examd. inhibitory activity against pancreatic lipase, which showed inhibition of 58.2%, 99.2% and 50.3% at concn. of 1 mg/mL, resp.