リ　ギ   Li Wei   李　巍    所属   東邦大学  薬学部 薬学科    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Lanostane-type triterpenoids from the roots of Kadsura coccinea
掲載誌名	正式名：Journal of natural products 略　 称：J Nat Prod ISSNコード：01633864
巻・号・頁	71(6),pp.990-994
著者・共著者	Nan Wang, Zhanlin Li, Dandan Song, Wei Li, Hongwei Fu, Kazuo Koike, Yuehu Pei, Yongkui Jing, Huiming Hua
発行年月	2008
概要	Seven new lanostane-type triterpenoids, seco-coccinic acids A-F (1-6) and coccinilactone A (7), were isolated from the roots of Kadsura coccinea. Their structures were established on the basis of spectroscopic data anal. The abs. configuration at C-24 of compd. 5 was confirmed by the modified Mosher's method. The cell growth inhibitory effects of these compds. were detd. in human leukemia HL-60 cells, and it was found that compds. 1, 2, 3, and 5 exhibited antiproliferative effects with GI50 values ranging from 6.8 to 42.1 .mu.M.