オザキ　イサム   Ozaki Isamu   尾﨑　勇    所属   東邦大学  医学部 医学科    職種   研究員（寄付講座）
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Effects of aging on central conduction in somatosensory evoked potentials: evaluation of onset versus peak methods
掲載誌名	正式名：CLINICAL NEUROPHYSIOLOGY ISSNコード：1388-2457
出版社	ELSEVIER SCI IRELAND LTD
巻・号・頁	110(12),pp.2094-2103
著者・共著者	M Tanosaki,Ozaki, I,H Shimamura,M Baba,M Matsunaga
発行年月	1999/12
概要	Objectives: To investigate effects of aging on peripheral and central somatosensory conduction, and evaluate onset-to-onset and peak-to-peak measurements of each component and central conduction time (CCT) in somatosensory evoked potentials (SEPs). Methods: We recorded SEPs with non-cephalic reference from the Erb's point, the posterior (cv 6) and anterior neck, and scalp (Fz and P4) after left median nerve stimulation in 138 normal subjects aged between 20 and 78 years. We determined onset or peak latencies of the Erb's potential (N9), the spinal N13-P13 in cv 6-to-anterior neck montage and the N20-P20 in scalp leads. Onset CCT was defined as a transit time from N13-P13 onset to N20-P20 onset. Ln each subject, interpeak latencies of the 'N13' component in cv 6-to-Fz montage and the N20-P20 in P4-to-Fz montage were also defined as conventional peak CCT. Results: Using multiregression analysis, we found that the onset or peak latencies of each SEP component were correlated with the subject's height and age. So were the onset CCTs: Onset CCT (in ms) = 2.549 + 2.041 x (height in meters) + 0.005 x (age in years) (P < 0.0001) The conventional peak CCTs as well as onset-to-peak durations of the N20-P20 were correlated with the subject's age but not height: Peak CCT(in ms)= 5.458 + 0.012x(age in years) (P < 0.0005). Conclusion: Conductive function is affected by normal aging in the central as well as peripheral somatosensory pathways. The peak CCT is more affected by aging than the onset CCT. However, the onset-to-peak duration of the N20-P20 increased by 0.8 ms between the 4th and 7th decades, suggesting that the peak CCT increase in older people reflects the age-related changes in N20-P20 profile but not in the fastest central conduction. We therefore conclude that the onset CCT measurement is preferable to the peak CCT measurement when assessing the central somatosensory conduction. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
DOI	10.1016/S1388-2457(99)00193-5
PMID	10616114