オザキ　イサム   Ozaki Isamu   尾﨑　勇    所属   東邦大学  医学部 医学科    職種   研究員（寄付講座）
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	The respiratory cycle modulates brain potentials, sympathetic activity, and subjective pain sensation induced by noxious stimulation
掲載誌名	正式名：NEUROSCIENCE RESEARCH ISSNコード：0168-0102/1872-8111
出版社	ELSEVIER IRELAND LTD
巻・号・頁	84,pp.47-59
著者・共著者	Tatsuya Iwabe,Isamu Ozaki,Akira Hashizume
発行年月	2014/07
概要	To test the hypothesis that a respiratory cycle influences pain processing, we conducted an experimental pain study in 10 healthy volunteers. Intraepidermal electrical stimulation (IES) with a concentric bipolar needle electrode was applied to the hand dorsum at pain perceptual threshold or four times the perceptual threshold to produce first pain during expiration or inspiration either of which was determined by the abrupt change in an exhaled CO2 level. IES-evoked potentials (IESEPs), sympathetic skin response (SSR), digital plethysmogram (DPG), and subjective pain intensity rating scale were simultaneously recorded. With either stimulus intensity, IES during expiration produced weaker pain feeling compared to IES during inspiration. The mean amplitude of N200/P400 in IESEPs and that of SSR were smaller when IES was applied during expiration. The magnitude of DPG wave gradually decreased after IES, but a decrease in the magnitude of DPG wave was less evident when IES was delivered during expiration. Regardless of stimulus timing or stimulus intensity, pain perception was always concomitant with appearance of IESEPs and SSR, and changes in DPG. Our findings suggest that pain processing fluctuates during normal breathing and that pain is gated within the central nervous system during expiration. (C) 2014 The Authors. Published by Elsevier Ireland Ltd and the Japan Neuroscience Society.
DOI	10.1016/j.neures.2014.03.003
PMID	24667456