フルタ トシアキ
Furuta Toshiaki
古田 寿昭 所属 東邦大学 理学部 生物分子科学科 職種 教授 |
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論文種別 | 総説 |
言語種別 | 英語 |
査読の有無 | 査読あり |
招待の有無 | 招待あり |
表題 | Designing caged compounds for spatiotemporal control of cellular chemistry |
掲載誌名 | 正式名:Journal of Synthetic Organic Chemistry, Japan |
掲載区分 | 国内 |
巻・号・頁 | 69(11),pp.1164-1169 |
著者・共著者 | T. Furuta |
担当区分 | 筆頭著者,責任著者 |
発行年月 | 2012/11 |
概要 | Photoirradiation of an appropriately designed caged compound enables the control and manipulation of biological processes in living cells with high spatial and temporal resolution. Brominated (coumarin-4-yl)methyl groups were designed to have favorable photochemical and physical properties as photoremovable protecting groups of caged compounds. Caged compounds of various types of biologically related molecules including neurotransmitters, second messengers, inhibitors of some proteins and mRNAs have been synthesized. A membrane-permeable caged cGMP, Bhc-cGMP/Ac, controlled a cGMP-dependent signaling pathway in a freely swimming sperm cell. Spot illumination of Bhcmoc-diC8 produced localized accumulation of diacylglycerol in a single T-cell. |