ニシオ　ジュンコ   Nishio Junko   西尾　純子    所属   東邦大学  医学部 医学科    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	A refractory case of adult-onset Still’s disease
掲載誌名	正式名：Japanese Journal of Clinical Immunology ISSNコード：1349-7413
巻・号・頁	20(3),pp.191-198
著者・共著者	Junko Nishio,Ryuji Koike,Hideki Iizuka,Toshihiro Nanki,Noboru Mizushima,Hitoshi Kohsaka,Tetsuo Kubota,Nobuyuki Miyasaka
発行年月	1997
概要	We report here a case of adult-onset Still’s disease (AOSD), who finally responded to a combination of cyclophosphamide (CPA) and gold sodium thiomalate (GST) after two years of active disease. A 23-year-old man having continuous high fever with skin rash, polyarthralgia and increased serum ferritin, was diagnosed as AOSD, and oral corticosteroid was initially effective. His symptoms reccured one year later without clinical improvement to increased dosage of steroid. He was admitted to our hospital with pericarditis and pleural effusion but did not respond to either intravenous (IV) pulse steroid therapy, methotrexate (MTX) or high dose IV γ-globulin. He was partly responsive to monthly IV injection of CPA, but clinical symptoms did not completely subside and hyperferritinemia persisted. GST, initiated in combination with CPA, however, was successful to induce complete remission. MTX has recently been reported to be efficacious to steroid-resistant AOSD, but CPA and gold compounds might be useful to refractory case of AOSD. © 1997, The Japan Society for Clinical Immunology. All rights reserved.
DOI	10.2177/jsci.20.191
PMID	9256612