ニシオ　ジュンコ   Nishio Junko   西尾　純子    所属   東邦大学  医学部 医学科    職種   准教授
論文種別	原著
言語種別	日本語
査読の有無	査読なし
表題	[Case of subcutaneous and mesenteric acute panniculitis with Sjögren's syndrome].
掲載誌名	正式名：Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology ISSNコード：0911-4300
掲載区分	国内
巻・号・頁	25(3),277-84頁
著者・共著者	Takahiko Sugihara,Rhuji Koike,Yurika Nosaka,Jun Ogawa,Hiroyuki Hagiyama,Kenji Nagasaka,Yoshinori Nonomura,Junko Nishio,Toshihiro Nanki,Hitoshi Kohsaka,Tetsuo Kubota,Nobuyuki Miyasaka
発行年月	2002/06
概要	We report a case of a 27-year-old Japanese female with Sjogren's syndrome (SS), who suffered from several episodes of subcutaneous and mesenteric panniculitis with a recurrence within one year. After a history of fever and skin rash, the patient underwent surgery at a local hospital with a diagnosis of acute appendicitis complicated with an ileocecal abscess. She was also diagnosed as having SS. After the operation, the fever and skin rash persisted. She was treated with prednisolone (PSL), and her symptoms resolved. A recurrent bout of abdominal pain with fever, annular erythema on the trunk and a nodular erythematous rash on the lower extremities occurred six months after the operation. A skin biopsy from the lower extremities showed findings that were compatible with panniculitis. Abdominal computer tomography (CT) showed a diffuse swelling with soft tissue density in the intestinal mesenterium and para aortic area. A retrospective examination of the operative specimen obtained from the local hospital revealed centrilobular infiltration of neutrophils in the mesenteric adipose tissue with fat necrosis, which is compatible with mesenteric panniculitis. Twenty mg/day of PSL was successful in treating the systemic panniculitis, and the abnormal diffuse soft tissue density on the abdominal CT disappeared after three weeks of PSL administration. Systemic panniculitis is a rare complication in SS, and the pathogenesis is unclear.
PMID	16578972