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ニシオ ジュンコ
Nishio Junko
西尾 純子 所属 東邦大学 医学部 医学科 職種 准教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution. |
| 掲載誌名 | 正式名：Science (New York, N.Y.) ISSNコード：/1095-9203 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 311(5768),pp.1775-8 |
| 著者・共著者 | Junko Nishio,Jason L Gaglia,Stuart E Turvey,Christopher Campbell,Christophe Benoist,Diane Mathis |
| 担当区分 | 筆頭著者 |
| 発行年月 | 2006/03/24 |
| 概要 | A cure for type 1 diabetes will probably require the provision or elicitation of new pancreatic islet beta cells as well as the reestablishment of immunological tolerance. A 2003 study reported achievement of both advances in the NOD mouse model by coupling injection of Freund's complete adjuvant with infusion of allogeneic spleen cells. It was concluded that the adjuvant eliminated anti-islet autoimmunity and the donor splenocytes differentiated into insulin-producing (presumably beta) cells, culminating in islet regeneration. Here, we provide data indicating that the recovered islets were all of host origin, reflecting that the diabetic NOD mice actually retain substantial beta cell mass, which can be rejuvenated/regenerated to reverse disease upon adjuvant-dependent dampening of autoimmunity. |
| PMID | 16556845 |