ニシオ　ジュンコ   Nishio Junko   西尾　純子    所属   東邦大学  医学部 医学科    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes.
掲載誌名	正式名：Immunity
掲載区分	国外
巻・号・頁	36(5),pp.731-41
著者・共著者	Jaime Darce,Dipayan Rudra,Li Li,Junko Nishio,Daniela Cipolletta,Alexander Y Rudensky,Diane Mathis,Christophe Benoist
発行年月	2012/05/25
概要	Maintenance of lymphoid homeostasis in a number of immunological and inflammatory contexts is served by a variety of regulatory T (Treg) cell subtypes and depends on interaction of the transcription factor FoxP3 with specific transcriptional cofactors. We report that a commonly used insertional mutant of FoxP3 (GFP-Foxp3) modified its molecular interactions, blocking HIF-1α but increasing IRF4 interactions. The transcriptional profile of these Treg cells was subtly altered, with an overrepresentation of IRF4-dependent transcripts. In keeping with IRF4-dependent function of Treg cells to preferentially suppress T cell help to B cells and Th2 and Th17 cell-type differentiation, GFP-FoxP3 mice showed a divergent susceptibility to autoimmune disease: protection against antibody-mediated arthritis in the K/BxN model, but greater susceptibility to diabetes on the NOD background. Thus, specific subfunctions of Treg cells and the immune diseases they regulate can be influenced by FoxP3's molecular interactions, which result in divergent immunoregulation.
DOI	10.1016/j.immuni.2012.04.007
PMID	22579475