ニシオ　ジュンコ   Nishio Junko   西尾　純子    所属   東邦大学  医学部 医学科    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses.
掲載誌名	正式名：eLife
掲載区分	国外
巻・号・頁	3,pp.e04177
著者・共著者	Shiho Chiba,Hiroaki Ikushima,Hiroshi Ueki,Hideyuki Yanai,Yoshitaka Kimura,Sho Hangai,Junko Nishio,Hideo Negishi,Tomohiko Tamura,Shinobu Saijo,Yoichiro Iwakura,Tadatsugu Taniguchi
発行年月	2014/08/22
概要	The eradication of tumor cells requires communication to and signaling by cells of the immune system. Natural killer (NK) cells are essential tumor-killing effector cells of the innate immune system; however, little is known about whether or how other immune cells recognize tumor cells to assist NK cells. Here, we show that the innate immune receptor Dectin-1 expressed on dendritic cells and macrophages is critical to NK-mediated killing of tumor cells that express N-glycan structures at high levels. Receptor recognition of these tumor cells causes the activation of the IRF5 transcription factor and downstream gene induction for the full-blown tumoricidal activity of NK cells. Consistent with this, we show exacerbated in vivo tumor growth in mice genetically deficient in either Dectin-1 or IRF5. The critical contribution of Dectin-1 in the recognition of and signaling by tumor cells may offer new insight into the anti-tumor immune system with therapeutic implications.
DOI	10.7554/eLife.04177
PMID	25149452