ニシオ　ジュンコ   Nishio Junko   西尾　純子    所属   東邦大学  医学部 医学科    職種   准教授
論文種別	原著
言語種別
査読の有無	査読あり
表題	Gallbladder-derived surfactant protein D regulates gut commensal bacteria for maintaining intestinal homeostasis
掲載誌名	正式名：Proceedings of the National Academy of Sciences ISSNコード：0027-8424/1091-6490
出版社	Proceedings of the National Academy of Sciences
巻・号・頁	114(38),10178-10183頁
著者・共著者	Hana Sarashina-Kida,Hideo Negishi,Junko Nishio,Wataru Suda,Yuki Nakajima,Mika Yasui-Kato,Keiko Iwaisako,Sujin Kang,Nobuyasu Endo,Hideyuki Yanai,Masataka Asagiri,Hiroshi Kida,Masahira Hattori,Atsushi Kumanogoh,Tadatsugu Taniguchi
担当区分	筆頭著者
発行年月	2017/09/06
概要	Significance The imbalance in the intestinal microbiota repertoire, called dysbiosis, underlies the development of inflammatory diseases in the intestine and distant organ systems. Whether and how distant organs regulate the commensal gut bacteria and intestinal homeostasis via microbe-targeted molecules has remained poorly explored. In this study, we show that the gallbladder regulates intestinal immune homeostasis through the production of surfactant protein D (SP-D) that is delivered to the intestine via bile. The importance of the gallbladder-derived SP-D was underscored by an intestinal dysbiosis in SP-D–deficient mice and susceptibility of these mice to dextran sodium sulfate sodium-induced colitis. Our study thus revealed a unique interorgan regulation of intestinal homeostasis by SP-D with potential clinical implications such as cholecystectomy.
DOI	10.1073/pnas.1712837114
PMID	28878025
PermalinkURL	http://www.pnas.org/syndication/doi/10.1073/pnas.1712837114
researchmap用URL	https://pnas.org/doi/pdf/10.1073/pnas.1712837114