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アンザイ ヨウジロウ
Yojiro Anzai
安齊 洋次郎 所属 東邦大学 薬学部 薬学科 職種 教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Maniwamycins: new quorum-sensing inhibitors against Chromobacterium violaceum CV026 were isolated from Streptomyces sp. TOHO-M025 |
| 掲載誌名 | 正式名：The Journal of Antibiotics ISSNコード：00218820 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 69(5),pp.395-399 |
| 著者・共著者 | Atsushi Fukumoto＊†, Chikana Murakami, Yojiro Anzai† and Fumio Kato† |
| 発行年月 | 2016/05 |
| 概要 | Quorum sensing is an important microbial signaling system that controls the expression of many virulence genes. Maniwamycins
C–F, new compounds and quorum-sensing inhibitors, were isolated from the culture broth of Streptomyces sp. TOHO-M025 using a silica gel column and preparative HPLC. The structures of maniwamycins were elucidated by spectroscopic analyses, including NMR. The compounds each have an azoxy moiety. All maniwamycins inhibited violacein synthesis, which is controlled by quorum sensing, in Chromobacterium violaceum CV026. |
| DOI | 10.1038/ja.2015.126 |