東邦大学 教育・研究業績データベース   
     


  ミカミ テツオ   Mikami Tetsuo
  三上 哲夫
   所属   東邦大学  医学部 医学科
   職種   教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Papillary thyroid carcinoma with heterotopic ossification is a special subtype with extensive progression
掲載誌名 正式名:American journal of clinical pathology
略  称:Am J Clin Pathol
ISSNコード:00029173
インパクトファクター 2.598
巻・号・頁 139(5),587-598頁
著者・共著者 Takeda M, Mikami T, Numata Y, Okamoto M, Okayasu I
発行年月 2013/05
概要 An immunohistochemical study was conducted of 108 papillary carcinoma cases, including 48 cases with intratumoral heterotopic ossification (IHO). In 48 cases, papillary carcinoma with IHO was accompanied by nodular fibrosis. Cases of papillary carcinoma with IHO or nodular fibrosis showed higher incidences of lymph node metastasis, multifocal lesions, and extrathyroidal invasion than those without IHO and nodular fibrosis. A higher number of stromal myofibroblasts was observed in papillary carcinoma with IHO or nodular fibrosis than in that without fibrosis. Expression of both basic fibroblast growth factor (bFGF) and bone morphogenetic protein (BMP)-2 was the highest in papillary carcinoma with IHO. Papillary carcinoma with IHO showed higher vascular invasion and higher numbers of capillaries expressing nestin, which is associated with high expression of vascular endothelial growth factor (VEGF). Papillary carcinoma with IHO is a unique subtype with extensive progression including frequent lymph node metastasis, multifocality, and invasive behavior. Papillary carcinoma with IHO was correlated with expression of bFGF, BMP-2, and VEGF in the carcinoma cells, leading to neovascularization.
DOI 10.1309/AJCPQZQN50HKIAHA
文献番号 23596110