東邦大学 教育・研究業績データベース   
     


  イトウ マサノリ   Ito Masanori
  伊藤 雅方
   所属   東邦大学  医学部 医学科
   職種   講師
論文種別 総説
言語種別 英語
査読の有無 査読あり
表題 Genome-wide application of RNAi to the discovery of potential drug targets.
掲載誌名 正式名:FEBS Letters
略  称:FEBS Lett
掲載区分国外
インパクトファクター 3.372
巻・号・頁 579(26),5988-5995頁
著者・共著者 Ito M, Kawano K, Miyagishi M, Taira K
発行年月 2006/10
概要 Progress is being made in the development of RNA interference-based (RNAi-based) strategies for the control of gene expression. It has been demonstrated that small interfering RNAs (siRNAs) can silence the expression of target genes in a sequence-specific manner in mammalian cells. Various groups, including our own, have developed systems for vector-mediated specific RNAi. Vector-based siRNA- (or shRNA) expression libraries directed against the entire human genome and siRNA libraries based on chemically synthesized oligonucleotides now allow the rapid identification of functional genes and potential drug targets. Use of such libraries will enhance our understanding of numerous biological phenomena and contribute to the rational design of drugs against heritable, infectious and malignant diseases.
DOI 10.1016/j.febslet.2005.08.015
文献番号 16153642