ミズノ　フヅキ   Mizuno Fuzuki   水野　文月    所属   東邦大学  医学部 医学科    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	MtDNA diversity of the Zapotec in Mexico suggests a population decline long before the first contact with Europeans
掲載誌名	正式名：Journal of Human Genetics 略　 称：JHG
掲載区分	国外
巻・号・頁	60,pp.557-559
著者・共著者	Gojobori J, Mizuno F†, Wang L, Onishi K, Granados J, Gomez-Trejo C, Acuña-Alonzo V, and Ueda S.
担当区分	2nd著者
発行年月	2015/05
概要	The New World is the last continent colonized by anatomically modern humans, Homo sapiens. The first migrants entered the New World from Asia through Beringia. It is suggested that there were three streams of Asian gene flow, one major and two additional minor gene flows. The first major migrants took a Pacific coastal route and began spreading to the American continent before the opening of the ice-free corridor. We investigated the diversity of full-length mitochondrial DNA genomes of the Zapotec population, residing in the Mesoamerican region, and reconstructed their demographic history using Bayesian Skyline Plots. We estimated the initial date of gene flow into the New World by Zapotec ancestors at around 17 000–19 000 years ago, which is highly concordant with previous studies. We also show a population decline after the initial expansion. This decline started 4000 years ago, long before European contact with Native Americans. This indicates that other factors including climate change should be considered to explain the observed demographic pattern.
DOI	doi: 10.1038/jhg.2015.55