ミズノ　フヅキ   Mizuno Fuzuki   水野　文月    所属   東邦大学  医学部 医学科    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Complete mitogenome analysis of indigenous population in Mexico: its relevance for the origin of Mesoamericans
掲載誌名	正式名：Journal of Human Genetics 略　 称：JHG ISSNコード：14345161/1435-232X
掲載区分	国外
巻・号・頁	59(7),pp.359-367
著者・共著者	Mizuno F†, Gojobori J, Wang L, Onishi K, Sugiyama S, Granados J, Gomez-Trejo C, Acuña-Alonzo V, Ueda S
担当区分	筆頭著者
発行年月	2014/07
概要	Mesoamerica has an important role in the expansion of Paleoamericans as the route to South America. In this study, we determined complete mitogenome sequences of 113 unrelated individuals from two indigenous populations of Mesoamerica, Mazahua and Zapotec. All newly sequenced mitogenomes could be classified into haplogroups A2, B2, C1 and D1, but one sequence in Mazahua was D4h3a, a subclade of haplogroup D4. This haplogroup has been mostly found in South America along the Pacific coast. Haplogroup X2a was not found in either population. Genetic similarity obtained using phylogenetic tree construction and principal component analysis showed that these two populations are distantly related to each other. Actually, the Mazahua and the Zapotec shared no sequences (haplotypes) in common, while each also showed a number of unique subclades. Surprisingly, Zapotec formed a cluster with indigenous populations living in an area from central Mesoamerica to Central America. By contrast, the Mazahua formed a group with indigenous populations living in external areas, including southwestern North America and South America. This intriguing genetic relationship suggests the presence of two paleo-Mesoamerican groups, invoking a scenario in which one group had expanded into South America and the other resided in Mesoamerica.
DOI	doi:10.1038/jhg.2014.35
文献番号	24804703