ヤマガタ　トモコ   Yamagata Tomoko   山形　朋子    所属   東邦大学  医学部 医学科    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	The hypothalamic link between arousal and sleep homeostasis in mice
掲載誌名	正式名：Proceedings of the National Academy of Sciences of the United States of America 略　 称：Proc. Natl. Acad. Sci. U. S. A. ISSNコード：00278424/10916490
掲載区分	国外
出版社	NATL ACAD SCIENCES
巻・号・頁	118(51),pp.e2101580118
国際共著	国際共著
著者・共著者	Tomoko Yamagata, Martin C. Kahn, José Prius-Mengual, Elise Meijer, Merima Šabanović, Mathilde C. C. Guillaumin, Vincent van der Vinne, Yi-Ge Huang, Laura E. McKillop, Aarti Jagannath, Stuart N. Peirson, Edward O. Mann, Russell G. Foster, and Vladyslav V. Vyazovskiy
担当区分	筆頭著者
発行年月	2021/12/13
概要	Sleep and wakefulness are not simple, homogenous all-or-none states but represent a spectrum of substates, distinguished by behavior, levels of arousal, and brain activity at the local and global levels. Until now, the role of the hypothalamic circuitry in sleep–wake control was studied primarily with respect to its contribution to rapid state transitions. In contrast, whether the hypothalamus modulates within-state dynamics (state “quality”) and the functional significance thereof remains unexplored. Here, we show that photoactivation of inhibitory neurons in the lateral preoptic area (LPO) of the hypothalamus of adult male and female laboratory mice does not merely trigger awakening from sleep, but the resulting awake state is also characterized by an activated electroencephalogram (EEG) pattern, suggesting increased levels of arousal. This was associated with a faster build-up of sleep pressure, as reflected in higher EEG slow-wave activity (SWA) during subsequent sleep. In contrast, photoinhibition of inhibitory LPO neurons did not result in changes in vigilance states but was associated with persistently increased EEG SWA during spontaneous sleep. These findings suggest a role of the LPO in regulating arousal levels, which we propose as a key variable shaping the daily architecture of sleep–wake states.